What is So Rare as a Day in June?

A h, June … when things are busting out all over. For example, in this issue, Durk & Sandy report on “Rapid New Advances in the Understanding of Senescence Leading To Practical Methods of Deterring Aging Such As Decreasing Loss of Muscle” and “The Triage Theory of Aging: Why Modest Inadequacy of Vitamins or Minerals May Increase Diseases of Aging Later.”

Many people are not aware of the importance of consuming higher amount of selenium, levels of which tend to decline with age. Did you know that selenium levels predict longevity? Also, you may not be aware that inadequate selenium concentrations can lead to diminished cell replicative lifetimes (cell senescence), and this in turn may play a key role in the process of sarcopenia, the age-associated loss of muscle. Another disease that has been linked to cell senescence (the failure to replicate) is osteoarthritis, which is accompanied by pain and disability. In fact, senescence can be transmitted to non-senescent neighboring cells thus hindering longevity. In addition to selenium, magnesium, zinc, and metformin may protect against premature senescence of your cells, but it is important to determine the right dose.

The Triage Theory of Aging represents what is potentially a very important new theory of aging. In summation, Durk & Sandy quote the authors of the paper “Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging,” “The most obvious value of the theory is that it provides a rationale for why a particular class of V/M [vitamin-mineral]-dependent proteins (i.e., those that are nonessential) may not be fully functional even at modest levels of V/M deficiency not accompanied by any obvious clinical signs. The value of this insight is that it suggests a strategy for identifying sensitive biomarkers of V/M deficiency and candidate proteins mechanistically linked to disease …”

Even among many “life enhancers” and “life extenders,” there is a dim awareness of how evolutionary needs (i.e., required for short-term survival and reproduction) triage the nutrients supplied even in what purports to be a comprehensive supplement program. This can lead to an increase in the threatening diseases of later life. Because even when the dietary availability of vitamins and minerals are moderately inadequate there may not be enough to serve higher needs, and to ward off degenerative diseases.

Please read these articles on pages 17–21 in this issue. If you act on the ideas presented, this June can become an important springboard into greater health.

Live long and prosper,

Will Block

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